Quarterback Lamar Jackson attempted only 19 passes in a game the team controlled until the final kick, losing in spectacular fashion via a Matt Prater walk-off field goal after leading by 15 points twice in the fourth quarter. The fantasy returns from the veteran tight end were particularly disappointing considering fellow tight end Isaiah Likely was unable to suit up. Andrews is never overly likely to see immense target volume considering his advanced age and the run-focused nature of the offense, gaining most of his value from his robust red zone role. It was veteran wide receiver DeAndre Hopkins that cashed in on a touchdown from just outside the red zone in this one, but it is worth noting that only one of the team’s five touchdowns came from within 20 yards. We should see better fantasy days ahead for Andrews, with managers hoping that start in Week 2 on the road against the Jets.

After a quiet first half that was dominated by Derrick Henry and Lamar Jackson, Flowers erupted for catches of 39 yards, 23 yards, and 36 yards to set a new career high in receiving with 143 yards. His touchdown came on his 23-yard grab in the third quarter that pushed Baltimore’s lead to 14 points. The nine targets also accounted for a robust 47.4 percent team target market share on just 19 Jackson pass attempts, with no other pass-catcher on the team seeing more than a modest four looks. Flowers and the Ravens draw another difficult matchup against the Jets on the road in Week 2.

The Ravens completely controlled the game on the legs of Henry and quarterback Lamar Jackson, with Henry amassing a ridiculous 123 yards and a score on nine first half carries. Henry also managed 86 yards after contact on the team’s first three possessions alone in what appeared to be a convincing road victory. Things sputtered in the second half for the Ravens even though Henry added another score from 46 yards out, punctuated by a fumble while nursing an eight point lead with just over three minutes remaining. Even with the disappointing loss, Henry reminded us all that Father Time has yet to catch up to his massive frame. He started his 2025 season on track to challenge 2,000 yards yet again.

The Ravens were in complete control of the game from the start of the second quarter through the middle of the fourth, leading by 15 twice in the final frame. An ill-timed fumble by Derrick Henry and two three-and-outs on their final three possessions allowed Josh Allen and the Bills to score 16 unanswered points in the final four minutes to steal victory from the Ravens, who fall to 0-1 ahead of a home meeting with the Browns in Week 2. Jackson looked the part of a two-time MVP while making multiple difficult throws throughout the game, the most beautiful of which was a dime to veteran wide receiver DeAndre Hopkins in the fourth quarter. Jackson remains an elite fantasy quarterback and appears primed to make another push towards league MVP in 2025.

Coleman and the rest of the Buffalo offense had a relatively quiet first half but scored 16 points in the final four minutes to steal the victory from the Ravens. Coleman’s touchdown went down as the first points in that span, which came on fourth down on a tipped pass off of tight end Dawson Knox’s hands. The incredible comeback win sends the Bills to a 1-0 record ahead of a road meeting with the Jets in Week 2.

Cook’s modest snap rates from 2024 carried into the first game of the 2025 season, but a touchdown plunge from two yards out in the third quarter and increased passing volume via negative game script propelled him to a usable fantasy week as the Bills stormed back in the fourth quarter to steal the victory from the Ravens. The Bills attempted 46 passes to just 16 running back carries while playing from behind throughout, something that isn’t likely to be the case against most opponents this season. Either way, Cook managed to return a solid score for fantasy managers that capitalized on his falling stock through his offseason hold-in. Up next is another difficult matchup on the ground against the Jets in Week 2.

The Ravens seemed to be running away with the game on the backs of Lamar Jackson and Derrick Henry, taking a 15-point lead into the fourth quarter. The Bills would cut the lead to nine early in the frame but Henry quickly answered with his second long score of the game. Allen then entered Super-Josh mode, leading two touchdown drives in under two minutes but the teams third failed two-point conversion left them down by two points with 1:58 left on the clock. The defense did their job and put the ball back into Allen’s hands and he would make them pay, connecting with deep passes to Josh Palmer and Keon Coleman to set Matt Prater up for a chip shot as time ran out. The late game heroics sent the Bills to a 1-0 record to start the 2025 regular season before they go on the road to face the 0-1 Jets in Week 2.

Nix posted a hideous 4.3 yards per attempt, missing open pass catchers and making baffling decisions in critical moments against a poor Tennessee defense. Nix tried to get something going as a rusher to no avail. Nix connected with his WR1 Courtland Sutton for his lone touchdown on a nicely throw red zone jump ball, but couldn’t get anything going in a game that should not have been close. Nix should continue giving fantasy managers a handful of rushing attempts every week, giving him some fantasy juice that can compensate for poor passing performances. Nix will be a borderline starting option in 12-team formats next week against the Colts.

Jennings injured his left shoulder in the 49ers’ Week 1 win over the Seahawks. Although he was initially deemed questionable to return, he spent the rest of the game on the sideline. The 49ers’ receiving corps is extremely thin, with Brandon Aiyuk (knee) still rehabbing and George Kittle (hamstring) also set to under an MRI and additional testing. Marquez Valdes-Scantling is the next man up. The error-prone speedster could catch one or two deep passes against his former team, the Saints, in Week 2.

Mims was bottled up on his three grabs and made some mental mistakes in the return game. The good news: Mims, a part-time gadget player last season, ran a pass route on 31 of Bo Nix’s 48 drop backs. Courtland Sutton and Troy Franklin had more routes than Mims on the day. Mims’ explosiveness on both short-area targets and downfield looks make him a high-variance weekly fantasy play. He gets the Colts in Week 2.